Inherited DNA-repair gene mutations in men with metastatic prostate cancer Academic Article uri icon

Overview

MeSH Major

  • DNA Repair
  • Germ-Line Mutation
  • Prostatic Neoplasms

abstract

  • In our multicenter study, the incidence of germline mutations in genes mediating DNA-repair processes among men with metastatic prostate cancer was 11.8%, which was significantly higher than the incidence among men with localized prostate cancer. The frequencies of germline mutations in DNA-repair genes among men with metastatic disease did not differ significantly according to age at diagnosis or family history of prostate cancer. (Funded by Stand Up To Cancer and others.).

authors

publication date

  • August 4, 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4986616

Digital Object Identifier (DOI)

  • 10.1056/NEJMoa1603144

PubMed ID

  • 27433846

Additional Document Info

start page

  • 443

end page

  • 53

volume

  • 375

number

  • 5