Memory of Inflammation in Regulatory T Cells Academic Article uri icon

Overview

MeSH Major

  • T-Lymphocytes, Regulatory

abstract

  • Eukaryotic cells can "remember" transient encounters with a wide range of stimuli, inducing lasting states of altered responsiveness. Regulatory T (Treg) cells are a specialized lineage of suppressive CD4 T┬ácells that act as critical negative regulators of inflammation in various biological contexts. Treg cells exposed to inflammatory conditions acquire strongly enhanced suppressive function. Using inducible genetic tracing, we analyzed the long-term stability of activation-induced transcriptional, epigenomic, and functional changes in Treg cells. We found that the inflammation-experienced Treg cell population reversed many activation-induced changes and lost its enhanced suppressive function over time. The "memory-less" potentiation of Treg suppressor function may help avoid a state of generalized immunosuppression that could otherwise result from repeated activation.

publication date

  • August 11, 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4996371

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2016.07.006

PubMed ID

  • 27499023

Additional Document Info

start page

  • 977

end page

  • 90

volume

  • 166

number

  • 4