Gray matter maturation and cognition in children with different APOE ϵ genotypes Academic Article uri icon

Overview

MeSH Major

  • Apolipoprotein E4
  • Brain
  • Cognition
  • Gray Matter

abstract

  • Our findings validated and extended prior smaller studies that showed altered brain development in APOE ε4-carrier children. The ε4ε4 and ε2ε4 genotypes may negatively influence brain development and brain aging at the extremes of age. Studying APOE ε polymorphisms in young children may provide the earliest indicators for individuals who might benefit from early interventions or preventive measures for future brain injuries and dementia.

publication date

  • August 9, 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4977368

Digital Object Identifier (DOI)

  • 10.1212/WNL.0000000000002939

PubMed ID

  • 27412137

Additional Document Info

start page

  • 585

end page

  • 94

volume

  • 87

number

  • 6