Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer Academic Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Gene Regulatory Networks
  • Mutation
  • Protein Kinase Inhibitors

abstract

  • Our study emphasizes the importance of PI3K/PTEN pathway activity in ER-negative and basal-like breast cancer and supports the future clinical evaluation of combining EGFR and PI3K pathway inhibitors for the treatment of BLBC.

publication date

  • August 2, 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4971667

Digital Object Identifier (DOI)

  • 10.1186/s12885-016-2609-2

PubMed ID

  • 27484095

Additional Document Info

start page

  • 587

volume

  • 16

number

  • 1