Maternal HIV infection influences the microbiome of HIV-uninfected infants Academic Article uri icon

Overview

MeSH Major

  • HIV Infections

abstract

  • More than 1 million HIV-exposed, uninfected infants are born annually to HIV-positive mothers worldwide. This growing population of infants experiences twice the mortality of HIV-unexposed infants. We found that although there were very few differences seen in the microbiomes of mothers with and without HIV infection, maternal HIV infection was associated with changes in the microbiome of HIV-exposed, uninfected infants. Furthermore, we observed that human breast milk oligosaccharides were associated with bacterial species in the infant microbiome. The disruption of the infant's microbiome associated with maternal HIV infection may contribute to the increased morbidity and mortality of HIV-exposed, uninfected infants.

publication date

  • July 27, 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5301310

Digital Object Identifier (DOI)

  • 10.1126/scitranslmed.aaf5103

PubMed ID

  • 27464748

Additional Document Info

start page

  • 349ra100

volume

  • 8

number

  • 349