S1P signaling and de novo biosynthesis in blood pressure homeostasis Review uri icon

Overview

MeSH Major

  • Blood Pressure
  • Homeostasis
  • Lysophospholipids
  • Signal Transduction
  • Sphingosine

abstract

  • Initially discovered as abundant components of eukaryotic cell membranes, sphingolipids are now recognized as important bioactive signaling molecules that modulate a variety of cellular functions, including those relevant to cancer and immunologic, inflammatory, and cardiovascular disorders. In this review, we discuss recent advances in our understanding of the role of sphingosine-1-phosphate (S1P) receptors in the regulation of vascular function, and focus on how de novo biosynthesized sphingolipids play a role in blood pressure homeostasis. The therapeutic potential of new drugs that target S1P signaling is also discussed.

publication date

  • August 2016

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4959106

Digital Object Identifier (DOI)

  • 10.1124/jpet.116.233205

PubMed ID

  • 27317800

Additional Document Info

start page

  • 359

end page

  • 70

volume

  • 358

number

  • 2