Therapeutic impact of cytoreductive surgery and irradiation of posterior fossa ependymoma in the molecular era: A retrospective multicohort analysis Academic Article uri icon

Overview

MeSH Major

  • Cytoreduction Surgical Procedures
  • Ependymoma
  • Infratentorial Neoplasms

abstract

  • The most impactful biomarker for posterior fossa ependymoma is molecular subgroup affiliation, independent of other demographic or treatment variables. However, both EPN_PFA and EPN_PFB still benefit from increased extent of resection, with the survival rates being particularly poor for subtotally resected EPN_PFA, even with adjuvant radiation therapy. Patients with EPN_PFB who undergo gross total resection are at lower risk for relapse and should be considered for inclusion in a randomized clinical trial of observation alone with radiation reserved for those who experience recurrence.

authors

publication date

  • July 20, 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4962737

Digital Object Identifier (DOI)

  • 10.1200/JCO.2015.65.7825

PubMed ID

  • 27269943

Additional Document Info

start page

  • 2468

end page

  • 77

volume

  • 34

number

  • 21