Can a Point-of-Care Troponin I Assay be as Good as a Central Laboratory Assay? A MIDAS Investigation. Academic Article Article uri icon

Overview

MeSH

  • Biomarkers
  • Emergency Service, Hospital
  • Humans
  • Laboratories
  • Myocardial Infarction
  • Prospective Studies
  • Reagent Kits, Diagnostic
  • Sensitivity and Specificity

MeSH Major

  • Acute Coronary Syndrome
  • Point-of-Care Systems
  • Troponin I

abstract

  • We aimed to compare the diagnostic accuracy of the Alere Triage Cardio3 Tropinin I (TnI) assay (Alere, Inc., USA) and the PathFast cTnI-II (Mitsubishi Chemical Medience Corporation, Japan) against the central laboratory assay Singulex Erenna TnI assay (Singulex, USA). Using the Markers in the Diagnosis of Acute Coronary Syndromes (MIDAS) study population, we evaluated the ability of three different assays to identify patients with acute myocardial infarction (AMI). The MIDAS dataset, described elsewhere, is a prospective multicenter dataset of emergency department (ED) patients with suspected acute coronary syndrome (ACS) and a planned objective myocardial perfusion evaluation. Myocardial infarction (MI) was diagnosed by central adjudication. The C-statistic with 95% confidence intervals (CI) for diagnosing MI by using a common population (n=241) was 0.95 (0.91-0.99), 0.95 (0.91-0.99), and 0.93 (0.89-0.97) for the Triage, Singulex, and PathFast assays, respectively. Of samples with detectable troponin, the absolute values had high Pearson (R(P)) and Spearman (R(S)) correlations and were R(P)=0.94 and R(S)=0.94 for Triage vs Singulex, R(P)=0.93 and R(S)=0.85 for Triage vs PathFast, and R(P)=0.89 and R(S)=0.73 for PathFast vs Singulex. In a single comparative population of ED patients with suspected ACS, the Triage Cardio3 TnI, PathFast, and Singulex TnI assays provided similar diagnostic performance for MI.

publication date

  • September 2016

has subject area

  • Acute Coronary Syndrome
  • Biomarkers
  • Emergency Service, Hospital
  • Humans
  • Laboratories
  • Myocardial Infarction
  • Point-of-Care Systems
  • Prospective Studies
  • Reagent Kits, Diagnostic
  • Sensitivity and Specificity
  • Troponin I

Research

keywords

  • Comparative Study
  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4940482

Digital Object Identifier (DOI)

  • 10.3343/alm.2016.36.5.405

PubMed ID

  • 27374704

Additional Document Info

start page

  • 405

end page

  • 412

volume

  • 36

number

  • 5