KIR3DL1 allelic polymorphism and HLA-B epitopes modulate response to Anti-GD2 monoclonal antibody in patients with neuroblastoma Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Monoclonal
  • Gangliosides
  • HLA-B Antigens
  • Neuroblastoma
  • Polymorphism, Genetic
  • Receptors, KIR3DL1

abstract

  • We conclude that KIR3LD1 and HLA-B allele combinations can have a prognostic impact on patient survival after treatment with anti-GD2 mAb that relies on NK-ADCC. The survival advantage seen in noninteracting combinations supports the therapeutic disinhibition of individuals with strongly interacting KIR and ligand pairs.

publication date

  • July 20, 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4962735

Digital Object Identifier (DOI)

  • 10.1200/JCO.2015.64.9558

PubMed ID

  • 27069083

Additional Document Info

start page

  • 2443

end page

  • 51

volume

  • 34

number

  • 21