Respiratory syncytial virus (RSV) pulmonary infection in humanized mice induces human anti-RSV immune responses and pathology Academic Article uri icon

Overview

MeSH Major

  • Lung
  • Lung Diseases
  • Respiratory Syncytial Virus Infections
  • Respiratory Syncytial Viruses
  • Respiratory Tract Infections

abstract

  • Infections with respiratory syncytial virus (RSV) are common and can cause severe lung disease in infants and the elderly. The lack of a suitable animal model with disease features similar to those in humans has hampered efforts to predict the efficacy of novel anti-RSV therapies and vaccines for use in humans. A murine model consisting of mice with a human immune system (HIS mice) could be useful for assessment of RSV disease and anti-RSV responses specific to humans. This study investigates an HIS mouse model to imitate human RSV disease and immune responses. We found that RSV lung infection in HIS mice results in an RSV-specific pathology that mimics RSV disease in humans and induces human anti-RSV immune responses. This model could be useful for better understanding of human RSV disease and for the development of RSV therapies.

publication date

  • May 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4859698

Digital Object Identifier (DOI)

  • 10.1128/JVI.00259-16

PubMed ID

  • 26962219

Additional Document Info

start page

  • 5068

end page

  • 74

volume

  • 90

number

  • 10