Selective repression of gene expression in neuropathic pain by the neuron-restrictive silencing factor/repressor element-1 silencing transcription (NRSF/REST) Review uri icon


MeSH Major

  • Epigenesis, Genetic
  • Gene Expression Regulation
  • Neuralgia
  • Repressor Proteins


  • Neuropathic pain often develops following nerve injury as a result of maladaptive changes that occur in the injured nerve and along the nociceptive pathways of the peripheral and central nervous systems. Multiple cellular and molecular mechanisms likely account for these changes; however, the exact nature of these mechanisms remain largely unknown. A growing number of studies suggest that alteration in gene expression is an important step in the progression from acute to chronic pain states and epigenetic regulation has been proposed to drive this change in gene expression. In this review, we discuss recent evidence that the DNA-binding protein neuron-restrictive silencing factor/repressor element-1 silencing transcription factor (NRSF/REST) is an important component in the development and maintenance of neuropathic pain through its role as a transcriptional regulator for a select subset of genes that it normally represses during development.

publication date

  • June 20, 2016



  • Review



  • eng

PubMed Central ID

  • PMC4899316

Digital Object Identifier (DOI)

  • 10.1016/j.neulet.2015.12.003

PubMed ID

  • 26679228

Additional Document Info

start page

  • 20

end page

  • 5


  • 625