Obesity but not high-fat diet impairs lymphatic function Academic Article uri icon

Overview

MeSH Major

  • Inflammation
  • Lymphatic Vessels
  • Lymphedema
  • Macrophages

abstract

  • Collectively, our studies suggest that HFD-induced obesity decreases lymphatic function by increasing perilymphatic inflammation and altering LEC gene expression. Reversal of diminished VEGFR-3 signaling may rescue this phenotype and improve lymphatic function.

publication date

  • October 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5050064

Digital Object Identifier (DOI)

  • 10.1038/ijo.2016.96

PubMed ID

  • 27200507

Additional Document Info

start page

  • 1582

end page

  • 1590

volume

  • 40

number

  • 10