Brain region-specific degeneration with disease progression in late infantile neuronal ceroid lipofuscinosis (CLN2 Disease) Academic Article uri icon

Overview

MeSH Major

  • Brain
  • Nerve Degeneration
  • Neuronal Ceroid-Lipofuscinoses

abstract

  • This study demonstrates that CLN2 causes differential rates of degeneration across the brain. Anatomic and functional regions that degenerate sooner and more severely than others compared with those in healthy controls may offer targets for directed therapies. The information gained may also provide neurobiologic insights regarding the mechanisms underlying disease progression.

publication date

  • June 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4907890

Digital Object Identifier (DOI)

  • 10.3174/ajnr.A4669

PubMed ID

  • 26822727

Additional Document Info

start page

  • 1160

end page

  • 9

volume

  • 37

number

  • 6