Transitional Cell Carcinoma Metastatic to Lung, With Dedifferentiation Into Small Cell Undifferentiated Carcinoma Academic Article uri icon


MeSH Major

  • Biopsy, Needle
  • Head and Neck Neoplasms
  • Ultrasonography, Interventional


  • Small-cell undifferentiated carcinoma (SCUC) has been increasingly recognized in the urinary tract.1,2,3 Up to 66% of SCUCs in this location are associated with a minor component of a more differentiated carcinoma that most frequently represents transi tional-cell carcinoma (TCC), but adenocarcinoma, squamous-cell carcinoma, spindle- cell carcinoma, and carcinoid carcinoma have all been described. We report a case of low-grade TCC of the urinary tract metastasizing to a distant location and therein dedifferentiating into an SCUC and discuss the clinical and biologic implication of the process of dedifferentiation. Int J Surg Pathol 2(2):157-162, 1994 © 1994, Sage Publications. All rights reserved.

publication date

  • January 1994



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1177/106689699400200211

Additional Document Info

start page

  • 157

end page

  • 162


  • 2


  • 2