Reliable detection of mismatch repair deficiency in colorectal cancers using mutational load in next-generation sequencing panels Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Colorectal Neoplasms
  • High-Throughput Nucleotide Sequencing
  • Mutation
  • Neoplastic Syndromes, Hereditary

abstract

  • A cutoff for mutational load can be identified via multigene NGS tumor profiling, which provides a highly accurate means of screening for MMR-D in the same assay that is used for tumor genotyping.

publication date

  • June 20, 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4962706

Digital Object Identifier (DOI)

  • 10.1200/JCO.2015.65.1067

PubMed ID

  • 27022117

Additional Document Info

start page

  • 2141

end page

  • 7

volume

  • 34

number

  • 18