Monoclonal gammopathy-associated pure red cell aplasia Academic Article uri icon

Overview

MeSH Major

  • Multiple Myeloma
  • Paraproteinemias
  • Red-Cell Aplasia, Pure

abstract

  • Pure red cell aplasia (PRCA) is a rare disorder characterized by inhibition of erythroid precursors in the bone marrow and normochromic, normocytic anaemia with reticulocytopenia. Among 51 PRCA patients, we identified 12 (24%) patients having monoclonal gammopathy, monoclonal gammopathy of undetermined significance or smouldering multiple myeloma, with presence of monoclonal protein or abnormal serum free light chains and atypical bone marrow features of clonal plasmacytosis, hypercellularity and fibrosis. Thus far, three patients treated with anti-myeloma based therapeutics have responded with reticulocyte recovery and clinical transfusion independence, suggesting plasma cells play a key role in the pathogenesis of this specific monoclonal gammopathy-associated PRCA.

publication date

  • June 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5549779

Digital Object Identifier (DOI)

  • 10.1111/bjh.14012

PubMed ID

  • 26999424

Additional Document Info

start page

  • 876

end page

  • 83

volume

  • 173

number

  • 6