Dynamic changes in neural circuitry during adolescence are associated with persistent attenuation of fear memories. In process uri icon

Overview

abstract

  • Fear can be highly adaptive in promoting survival, yet it can also be detrimental when it persists long after a threat has passed. Flexibility of the fear response may be most advantageous during adolescence when animals are prone to explore novel, potentially threatening environments. Two opposing adolescent fear-related behaviours-diminished extinction of cued fear and suppressed expression of contextual fear-may serve this purpose, but the neural basis underlying these changes is unknown. Using microprisms to image prefrontal cortical spine maturation across development, we identify dynamic BLA-hippocampal-mPFC circuit reorganization associated with these behavioural shifts. Exploiting this sensitive period of neural development, we modified existing behavioural interventions in an age-specific manner to attenuate adolescent fear memories persistently into adulthood. These findings identify novel strategies that leverage dynamic neurodevelopmental changes during adolescence with the potential to extinguish pathological fears implicated in anxiety and stress-related disorders.

publication date

  • May 24, 2016

Research

keywords

  • In press

Identity

Language

  • eng

PubMed Central ID

  • PMC4890178

Digital Object Identifier (DOI)

  • 10.1038/ncomms11475

PubMed ID

  • 27215672

Additional Document Info

start page

  • 11475

volume

  • 7