Antibiotic-Induced Changes in the Intestinal Microbiota and Disease Review uri icon

Overview

MeSH Major

  • Anti-Bacterial Agents
  • Bacteria
  • Gastrointestinal Microbiome

abstract

  • The gut microbiota is a key player in many physiological and pathological processes occurring in humans. Recent investigations suggest that the efficacy of some clinical approaches depends on the action of commensal bacteria. Antibiotics are invaluable weapons to fight infectious diseases. However, by altering the composition and functions of the microbiota, they can also produce long-lasting deleterious effects for the host. The emergence of multidrug-resistant pathogens raises concerns about the common, and at times inappropriate, use of antimicrobial agents. Here we review the most recently discovered connections between host pathophysiology, microbiota, and antibiotics highlighting technological platforms, mechanistic insights, and clinical strategies to enhance resistance to diseases by preserving the beneficial functions of the microbiota.

publication date

  • June 2016

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4885777

Digital Object Identifier (DOI)

  • 10.1016/j.molmed.2016.04.003

PubMed ID

  • 27178527

Additional Document Info

start page

  • 458

end page

  • 78

volume

  • 22

number

  • 6