Adenoviral Vectors Vaccine: Capsid Incorporation of Antigen
Continuous Positive Airway Pressure
© 2016 Elsevier Inc. All rights reserved.Adenovirus (Ad) vectors are attractive delivery vehicles for genetic vaccines. Conventional Ad transgene expression vaccines are partly affected by anti-Ad immunity in the general population. The generation of antivector immunity after immune priming further limits the efficacy of homologous boost immunizations. Based on the high immunogenicity of native Ad capsid proteins, display of immunogenic epitopes of pathogens on Ad capsids to induce pathogen-specific immunity has been proposed. This antigen capsid incorporation strategy can circumvent preexisting anti-Ad immunity and allow boosting of epitope-specific humoral immunity. The outer Ad capsid proteins of Ad that have been targets for genetic modification include fiber, penton base, protein IX, and hexon. Capsid-incorporated Ad vectors offer a novel vaccine platform that could be used either independently or combined with transgene expression to protect against infectious diseases.
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