More with Less: A Trial of Reduced-Intensity Treatment in Transplant-Ineligible Hemodialysis Patients. In process uri icon



  • An increasing proportion of hemodialysis patients are ineligible for transplant. Often these patients are elderly, with multiple comorbidities and decreased functional status. Such patients may benefit from modified treatment goals to reduce symptom burden. To demonstrate the feasibility of a trial of reduced-intensity treatment in nontransplantable patients with end-stage renal disease (ESRD). A 6-week study randomized patients to a reduced-intensity intervention versus usual care. Intervention subjects were treated with liberalized goals for serum phosphorus and parathyroid hormone (PTH) as well as predialysis blood pressure in comparison with usual care subjects. Outcomes included assessed feasibility of recruitment, randomization, and data collection. Sixteen transplant-ineligible hemodialysis patients were recruited from two urban units. Blood pressure was recorded weekly, while serum PTH and phosphorus were assessed every 10 days. A quality-of-life measure was administered before and after the trial. Of 300 patients, 51 were eligible and 16 consented. All were randomized and completed the trial. Patients in the intervention group received significantly lower doses of phosphorus binders and vitamin D analogues, and were less likely to have their dry weight reduced. All patient surveys were completed. High-risk hemodialysis patients may benefit from liberalized treatment guidelines but larger studies are necessary.

publication date

  • May 2016



  • In press



  • eng

PubMed Central ID

  • PMC4860662

Digital Object Identifier (DOI)

  • 10.1089/jpm.2015.0338

PubMed ID

  • 27139523

Additional Document Info

start page

  • 503

end page

  • 508


  • 19


  • 5