Comparison of Pediatric Severe Sepsis Managed in U.S. and European ICUs
Intensive Care Units, Pediatric
Practice Patterns, Physicians'
Severity of Illness Index
Children with severe sepsis admitted to European PICUs have higher severity of illness, are more likely to be admitted from hospital wards, and receive more intensive care therapies than in the United States. The lack of significant differences in morbidity and mortality after adjusting for patient characteristics suggests that the approach to care between regions, perhaps related to PICU bed availability, needs to be considered in the design of future international clinical trials in pediatric severe sepsis.