Nevospheres from neurocutaneous melanocytosis cells show reduced viability when treated with specific inhibitors of NRAS signaling pathway Academic Article uri icon

Overview

MeSH Major

  • Apoptosis
  • Benzimidazoles
  • Brain Neoplasms
  • GTP Phosphohydrolases
  • Melanoma
  • Membrane Proteins
  • Skin Neoplasms
  • Spheroids, Cellular

abstract

  • NRAS mutated cells derived from clinical NCM samples are capable of continuous growth as spheroid colonies in vitro and retain their genetic identity. Drugs targeting the NRAS signaling pathway reduce in vitro viability of NCM cells. NCM lesional spheroids represent a new and reliable experimental model of NCM for use in drug testing and mechanistic studies.

publication date

  • April 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4799680

Digital Object Identifier (DOI)

  • 10.1093/neuonc/nov184

PubMed ID

  • 26354928

Additional Document Info

start page

  • 528

end page

  • 37

volume

  • 18

number

  • 4