Folliculocentric Herpes: A Clinicopathological Study of 28 Patients Academic Article uri icon


MeSH Major

  • Hair Diseases
  • Hair Follicle
  • Herpes Zoster


  • Cutaneous herpetic eruptions can evoke a predominantly folliculocentric mononuclear cell reaction and vasculitis; there is an association with underlying endogenous and/or iatrogenic immune dysregulation. Most cases are secondary to reactivation of varicella zoster. The histomorphology suggests a role for cell-mediated immunity. Antigenic homology of an endogenous 72-kd heat shock protein in follicles with that of a herpetic heat shock protein, in concert with an intrafollicular proliferative response of γ-δ T lymphocytes, may explain the follicular localization and composition of the infiltrate.

publication date

  • May 3, 2016



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1097/DAD.0000000000000585

PubMed ID

  • 27149333

Additional Document Info