Intratracheal Gene Delivery of SERCA2a Ameliorates Chronic Post-Capillary Pulmonary Hypertension: A Large Animal Model Academic Article uri icon

Overview

MeSH Major

  • Gene Transfer Techniques
  • Hypertension, Pulmonary
  • Sarcoplasmic Reticulum Calcium-Transporting ATPases

abstract

  • Airway-based delivery of AAV vectors to the pulmonary arteries was feasible, efficient, and safe in a clinically relevant chronic PH model. Vascular SERCA2a overexpression resulted in beneficial effects on pulmonary arterial remodeling, with attendant improvements in pulmonary hemodynamics and RV performance, and might offer therapeutic benefit by modifying fundamental pathophysiology in pulmonary vascular diseases.

publication date

  • May 3, 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2016.02.049

PubMed ID

  • 27126531

Additional Document Info

start page

  • 2032

end page

  • 46

volume

  • 67

number

  • 17