DNMT3A haploinsufficiency transforms FLT3ITD myeloproliferative disease into a rapid, spontaneous, and fully penetrant acute myeloid leukemia Academic Article uri icon

Overview

MeSH Major

  • DNA (Cytosine-5-)-Methyltransferase
  • Haploinsufficiency
  • Leukemia, Myeloid, Acute
  • Myeloproliferative Disorders
  • Penetrance
  • Tandem Repeat Sequences
  • fms-Like Tyrosine Kinase 3

abstract

  • DNMT3A haploinsufficiency results in reversible epigenetic alterations that transform FLT3(ITD)-mutant myeloproliferative neoplasm into AML. Cancer Discov; 6(5); 501-15. ©2016 AACR.This article is highlighted in the In This Issue feature, p. 461.

publication date

  • May 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4861898

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-16-0008

PubMed ID

  • 27016502

Additional Document Info

start page

  • 501

end page

  • 15

volume

  • 6

number

  • 5