X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome Academic Article uri icon

Overview

MeSH Major

  • Arthritis, Rheumatoid
  • Liver Cirrhosis, Biliary
  • Lupus Erythematosus, Systemic
  • Sex Chromosome Disorders of Sex Development
  • Sjogren's Syndrome

abstract

  • The estimated prevalence of SLE and SS in women with 47,XXX was ∼2.5 and ∼2.9 times higher, respectively, than that in women with 46,XX and ∼25 and ∼41 times higher, respectively, than that in men with 46,XY. No statistically significant increase of 47,XXX was observed in other female-biased diseases (primary biliary cirrhosis or RA), supporting the idea of multiple pathways to sex bias in autoimmunity.

authors

publication date

  • May 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5019501

Digital Object Identifier (DOI)

  • 10.1002/art.39560

PubMed ID

  • 26713507

Additional Document Info

start page

  • 1290

end page

  • 300

volume

  • 68

number

  • 5