Lysine fatty acylation promotes lysosomal targeting of TNF-α Academic Article uri icon


MeSH Major

  • Lysine
  • Lysosomes
  • Tumor Necrosis Factor-alpha


  • Tumor necrosis factor-α (TNF-α) is a proinflammation cytokine secreted by various cells. Understanding its secretive pathway is important to understand the biological functions of TNF-α and diseases associated with TNF-α. TNF-α is one of the first proteins known be modified by lysine fatty acylation (e.g. myristoylation). We previously demonstrated that SIRT6, a member of the mammalian sirtuin family of enzymes, can remove the fatty acyl modification on TNF-α and promote its secretion. However, the mechanistic details about how lysine fatty acylation regulates TNF-α secretion have been unknown. Here we present experimental data supporting that lysine fatty acylation promotes lysosomal targeting of TNF-α. The result is an important first step toward understanding the biological functions of lysine fatty acylation.

publication date

  • April 15, 2016



  • Academic Article



  • eng

PubMed Central ID

  • PMC4832147

Digital Object Identifier (DOI)

  • 10.1038/srep24371

PubMed ID

  • 27079798

Additional Document Info

start page

  • 24371


  • 6