Differential NFATc1 Expression in Primary Cutaneous CD4+ Small/Medium-Sized Pleomorphic T-Cell Lymphoma and Other Forms of Cutaneous T-Cell Lymphoma and Pseudolymphoma Academic Article uri icon


MeSH Major

  • Biomarkers, Tumor
  • Lymphoma, T-Cell, Cutaneous
  • NFATC Transcription Factors
  • Pseudolymphoma
  • Skin Neoplasms


  • NFAT signaling plays a critical role in peripheral T-cell activation after T cell receptor engagement. When assessing T-cell-rich infiltrates where the differential diagnosis is largely between a PCSTCL and pseudolymphoma, a significant degree of nuclear staining of lymphocytes would be more in keeping with a diagnosis of PCSTCL. Upregulation of the NFAT pathway is not a feature of tumor progression in the setting of MF.

publication date

  • April 19, 2016



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1097/DAD.0000000000000597

PubMed ID

  • 27097342

Additional Document Info