Extended Amygdala to Ventral Tegmental Area Corticotropin-Releasing Factor Circuit Controls Binge Ethanol Intake Academic Article uri icon

Overview

MeSH Major

  • Consummatory Behavior
  • GABAergic Neurons
  • Hypothalamus

abstract

  • We provide novel evidence that 1) blunted binge-like ethanol consumption stemming from CRF1R blockade requires intact CRF2R signaling, and CRF2R activation reduces binge-like drinking; 2) inhibiting VTA-projecting BNST CRF neurons attenuates binge-like drinking; and 3) binge-like ethanol drinking alters protein and messenger RNA associated with the VTA-CRF system. These data suggest that ethanol-induced activation of BNST-to-VTA CRF projections is critical in driving binge-like ethanol intake.

publication date

  • July 22, 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5010800

Digital Object Identifier (DOI)

  • 10.1016/j.biopsych.2016.02.029

PubMed ID

  • 27113502

Additional Document Info