The impact of disease activity and tumour necrosis factor-α inhibitor therapy on cytokine levels in juvenile idiopathic arthritis
Gene Expression Regulation
Tumor Necrosis Factor-alpha
JIA subjects with increased disease activity at baseline had higher serum pro-inflammatory cytokines. TNF-α inhibition resulted in suppression of IL-6 and IL-8 in parallel with clinical improvement in all anti-TNF treated subjects, but also was associated with elevated TNF-α and IL-17 in etanercept treated subjects. This article is protected by copyright. All rights reserved.