Outcome of genetic evaluation of patients with kidney cancer referred for suspected hereditary cancer syndromes
Carcinoma, Renal Cell
Colorectal Neoplasms, Hereditary Nonpolyposis
Neoplastic Syndromes, Hereditary
The discovery of inherited kidney cancer syndromes has provided a unique opportunity to identify patients at increased risk for cancer. Factors associated with positive genetic testing are unique to different syndromes. These data suggest that in kidney cancer patients evaluated for hereditary cancer syndromes, young age is associated with diagnosis of RCC syndromes, whereas syndromic manifestations and multiple primaries are found in Lynch syndrome. These results, along with clinical awareness, may be useful for practicing urologists to select patients with kidney cancer to refer for genetic counseling.