The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice Academic Article uri icon

Overview

MeSH Major

  • Heterografts
  • Leukemia
  • Lymphoma
  • Tissue Banks
  • Xenograft Model Antitumor Assays

abstract

  • More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX) in mice could efficiently define therapeutic activity across heterogeneous tumors. To address this hypothesis, we established a large, publicly available repository of well-characterized leukemia and lymphoma PDXs that undergo orthotopic engraftment, called the Public Repository of Xenografts (PRoXe). PRoXe includes all de-identified information relevant to the primary specimens and the PDXs derived from them. Using this repository, we demonstrate that large studies of acute leukemia PDXs that mimic human randomized clinical trials can characterize drug efficacy and generate transcriptional, functional, and proteomic biomarkers in both treatment-naive and relapsed/refractory disease.

authors

publication date

  • April 11, 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5177991

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2016.03.008

PubMed ID

  • 27070704

Additional Document Info

start page

  • 574

end page

  • 86

volume

  • 29

number

  • 4