BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers Academic Article uri icon

Overview

MeSH Major

  • BRCA2 Protein
  • Breast Neoplasms
  • Codon, Terminator
  • Ovarian Neoplasms
  • Polymorphism, Single Nucleotide
  • Prostatic Neoplasms

abstract

  • Our study provides evidence that the K3326X variant is associated with risk of developing breast and ovarian cancers independent of other pathogenic variants in BRCA2. Further studies are needed to determine the biological mechanism of action responsible for these associations.

authors

publication date

  • February 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4907358

Digital Object Identifier (DOI)

  • 10.1093/jnci/djv315

PubMed ID

  • 26586665

Additional Document Info

volume

  • 108

number

  • 2