Identification of targetable kinase alterations in patients with colorectal carcinoma that are preferentially associated with wild-type RAS/RAF Academic Article uri icon

Overview

MeSH Major

  • Colorectal Neoplasms
  • MAP Kinase Kinase 1
  • Mutation
  • Receptor Protein-Tyrosine Kinases
  • raf Kinases
  • ras Proteins

abstract

  • Targetable kinase alterations were identified in a subset of advanced colorectal carcinoma patients, preferentially associated with wild-type RAS/RAF, and may predict poor response to standard anti-EGFR therapy.

publication date

  • March 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4972456

Digital Object Identifier (DOI)

  • 10.1158/1541-7786.MCR-15-0392-T

PubMed ID

  • 26660078

Additional Document Info

start page

  • 296

end page

  • 301

volume

  • 14

number

  • 3