Radioresistance of brain tumors Review uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Radiosurgery

abstract

  • Radiation therapy (RT) is frequently used as part of the standard of care treatment of the majority of brain tumors. The efficacy of RT is limited by radioresistance and by normal tissue radiation tolerance. This is highlighted in pediatric brain tumors where the use of radiation is limited by the excessive toxicity to the developing brain. For these reasons, radiosensitization of tumor cells would be beneficial. In this review, we focus on radioresistance mechanisms intrinsic to tumor cells. We also evaluate existing approaches to induce radiosensitization and explore future avenues of investigation.

publication date

  • March 30, 2016

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4846851

Digital Object Identifier (DOI)

  • 10.3390/cancers8040042

PubMed ID

  • 27043632

Additional Document Info

volume

  • 8

number

  • 4