Ablation of B7-H3 but not B7-H4 results in highly increased tumor burden in a murine model of spontaneous prostate cancer Academic Article uri icon

Overview

MeSH Major

  • B7 Antigens
  • Gene Deletion
  • Prostatic Neoplasms
  • V-Set Domain-Containing T-Cell Activation Inhibitor 1

abstract

  • The costimulatory molecules B7-H3 and B7-H4 are overexpressed in a variety of human tumors and have been hypothesized as possible biomarkers and immunotherapeutic targets. Despite this potential, the predominating uncertainty about their functional implication in tumor-host interaction hampers their evaluation as a target for cancer therapy. By means of a highly physiologic, spontaneous tumor model in mice, we establish a causal link between B7-H3 and host tumor control and found B7-H4 to be redundant.

publication date

  • August 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1158/2326-6066.CIR-15-0100

PubMed ID

  • 26122284

Additional Document Info

start page

  • 849

end page

  • 54

volume

  • 3

number

  • 8