Epidermotropic B-Cell Lymphoma: A Unique Subset of CXCR3-Positive Marginal Zone Lymphoma Review uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Lymphoma, B-Cell, Marginal Zone
  • Receptors, CXCR3
  • Skin Neoplasms

abstract

  • Epidermotropic B-cell lymphoma represents a subset of marginal zone lymphoma characterized by a papulosquamous rash most frequently resembling pityriasis rosea, occurring almost exclusively in older males. We speculate that aberrant expression of CXCR3 in marginal zone lymphoma of the skin is associated with migration of lymphoma cells to the epidermis and could lead to an epidermotropic pattern given the known role of CXCR3 expression in neoplastic T cells in the localization of mycosis fungoides to the epidermis. There is a tendency toward bone marrow, spleen, and peripheral blood involvement.

publication date

  • February 2016

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/DAD.0000000000000401

PubMed ID

  • 26275313

Additional Document Info

start page

  • 105

end page

  • 12

volume

  • 38

number

  • 2