Stress granules and RNA processing bodies are novel autoantibody targets in systemic sclerosis Academic Article uri icon

Overview

MeSH Major

  • Autoantibodies
  • Autoantigens
  • RNA Processing, Post-Transcriptional
  • Scleroderma, Systemic

abstract

  • While strong reactivity was observed against major SSc autoantigens, such as RNAP3 and TOP1, there was overlap between groups with widespread reactivity seen against multiple proteins. Identification of PB and SG as major targets of the humoral immune response represents a novel SSc autoantigen and suggests a model in which a combination of chronic and acute cellular stresses result in aberrant cell death, leading to autoantibody generation directed against macromolecular nucleic acid-protein complexes.

publication date

  • January 22, 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4724133

Digital Object Identifier (DOI)

  • 10.1186/s13075-016-0914-4

PubMed ID

  • 26801089

Additional Document Info

start page

  • 27

volume

  • 18

number

  • 1