Drug-drug interactions in older patients with cancer: A report from the 15th Conference of the International Society of Geriatric Oncology, Prague, Czech Republic, November 2015 Academic Article uri icon


MeSH Major

  • Clinical Trials as Topic
  • Neoplasms


  • Drugs taken for cancer can interact with each other, with agents taken as part of supportive care, with drugs taken for comorbid conditions (which are particularly common in the elderly patients), and with herbal supplements and complementary medicines. We tend to focus on the narrow therapeutic window of cytotoxics, but the metabolism of tyrosine kinase inhibitors by the cytochrome P450 3A4 enzyme (CYP3A4) makes some TKIs particularly prone to interference with or from other agents sharing this pathway. There is also potential for adverse pharmacokinetic interactions with new hormonal agents used in advanced prostate cancer.

publication date

  • January 14, 2016



  • Academic Article



  • eng

PubMed Central ID

  • PMC4720490

Digital Object Identifier (DOI)

  • 10.3332/ecancer.2016.611

PubMed ID

  • 26823680

Additional Document Info

start page

  • 611


  • 10