Integration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Glioma
  • Glutarates
  • Isocitrate Dehydrogenase
  • Practice Guidelines as Topic
  • Proton Magnetic Resonance Spectroscopy

abstract

  • Our study demonstrates that 2HG-MRS can be linked with routine MR imaging to provide quantitative measurements of 2HG in glioma and may be useful as an imaging biomarker to monitor the abundance of IDH-mutant tumor cells noninvasively during glioma therapy and disease monitoring.

publication date

  • February 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4724186

Digital Object Identifier (DOI)

  • 10.1093/neuonc/nov307

PubMed ID

  • 26691210

Additional Document Info

start page

  • 283

end page

  • 90

volume

  • 18

number

  • 2