A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics Academic Article uri icon

Overview

MeSH Major

  • Neuroendocrine Tumors
  • Pancreatic Neoplasms

abstract

  • This study involves a comprehensive cross-species integrated analysis of multi-omics profiles and histology to stratify PanNETs into subtypes with distinctive characteristics. We provide support for the RIP1-TAG2 mouse model as representative of its cognate human cancer with prospects to better understand PanNET heterogeneity and consider future applications of personalized cancer therapy.

publication date

  • December 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4946251

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-15-0068

PubMed ID

  • 26446169

Additional Document Info

start page

  • 1296

end page

  • 313

volume

  • 5

number

  • 12