Concurrent functional and metabolic assessment of brain tumors using hybrid PET/MR imaging Academic Article uri icon


MeSH Major

  • Brain Neoplasms
  • Magnetic Resonance Imaging
  • Positron-Emission Tomography


  • To evaluate diagnostic accuracy of perfusion weighted imaging (PWI) and positron emission tomography (PET) using an integrated PET/MR system in tumor grading as well as in differentiating recurrent tumor from treatment-induced effects (TIE) in brain tumor patients. Twenty patients (Group A: treatment naïve, 9 patients with 16 lesions; Group B: post-therapy, 11 patients with 18 lesions) underwent fluorine 18 ((18)F) fluorodeoxyglucose (FDG) brain PET/MR with PWI. Two blinded readers predicted low versus high-grade tumor (for Group A) and tumor recurrence versus TIE (for Group B) based solely on tumor rCBV (regional cerebral blood volume) and SUV (standardized uptake values). Tumor histopathology at resection was the reference standard. Using rCBVmean ≤ 1.74 as a cut-off, 100 % sensitivity and 74 % specificity were observed, whereas 75 % sensitivity and 89.7 % specificity were observed with SUVmean ≤ 4.0 as a cut-off to classify patients as test positive for low-grade tumors (Group A) and TIE (Group B). Diagnostic accuracy for detection of low-grade tumors was 90 % using PWI and 40 % using PET in Group A (p = 0.056); for detection of TIE in Group B, diagnostic accuracy was 94.1 % using PWI and 55.6 % using PET (p = 0.033). No significant correlation was demonstrated between rCBV parameters and SUV in Group A (mean values: p > 0.403), Group B (p > 0.06) and in the entire population (p > 0.07). Best overall sensitivity and specificity were obtained using rCBVmean ≤ 1.74 and SUVmean ≤ 4.0 cut-off values. PWI demonstrated better diagnostic accuracy in both groups. Poor correlation was observed between FDG and rCBV parameters.

publication date

  • April 2016



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1007/s11060-015-2032-6

PubMed ID

  • 26729270

Additional Document Info

start page

  • 287

end page

  • 93


  • 127


  • 2