Association of Forced Vital Capacity with the Developmental Gene NCOR2
Forced Expiratory Volume
Genetic Association Studies
Nuclear Receptor Co-Repressor 2
We have identified a new gene, NCOR2, in the retinoic acid signalling pathway pointing to a role of vitamin A metabolism in the regulation of FVC. Our findings also support SERPINE2, a COPD gene with weak previous evidence of association with FVC, and suggest WNT16 as a further promising candidate.