MYC immunohistochemistry to identify MYC-driven B-cell lymphomas in clinical practice
In Situ Hybridization, Fluorescence
Lymphoma, Large B-Cell, Diffuse
Proto-Oncogene Proteins c-myc
Under optimal conditions, clinically reported MYC IHC scores are concordant with expert scores within 15%. MYC IHC does not capture all B-cell lymphomas with MYC rearrangements, however. MYC IHC and MYC fluorescence in situ hybridization are both recommended to identify MYC-driven B-cell lymphomas.