Sleep disturbances in voltage-gated potassium channel antibody syndrome Academic Article uri icon


MeSH Major

  • Heart Rate
  • Polysomnography
  • REM Sleep Behavior Disorder
  • Sleep, REM


  • Voltage-gated potassium channels (VGKCs) are a family of membrane proteins responsible for controlling cell membrane potential. The presence of antibodies (Ab) against neuronal VGKC complexes aids in the diagnosis of idiopathic and paraneoplastic autoimmune neurologic disorders. The diagnosis of VGKC Ab-associated encephalopathy (VCKC Ab syndrome) should be suspected in patients with subacute onset of disorientation, confusion, and memory loss in the presence of seizures or a movement disorder. VGKC Ab syndrome may present with sleep-related symptoms, and the purpose of this communication is to alert sleep and neurology clinicians of this still-under-recognized condition. In this case, we are presenting the VGKC Ab syndrome which improved after treatment with solumedrol. The prompt recognition and treatment of this condition may prevent the morbidity associated with cerebral atrophy and the mortality associated with intractable seizures and electrolyte disturbances.

publication date

  • May 2016



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.sleep.2015.11.012

PubMed ID

  • 26922624

Additional Document Info

start page

  • 171

end page

  • 3


  • 21