Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer Academic Article uri icon

Overview

MeSH Major

  • Cadherins
  • Plasmacytoma
  • Urinary Bladder Neoplasms

abstract

  • Plasmacytoid bladder cancer is an aggressive histologic variant with a high risk of disease-specific mortality. Using whole-exome and targeted sequencing, we find that truncating somatic alterations in the CDH1 gene occur in 84% of plasmacytoid carcinomas and are specific to this histologic variant. Consistent with the aggressive clinical behavior of plasmacytoid carcinomas, which frequently recur locally, CRISPR/Cas9-mediated knockout of CDH1 in bladder cancer cells enhanced cell migration.

publication date

  • March 29, 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4827439

Digital Object Identifier (DOI)

  • 10.1038/ng.3503

PubMed ID

  • 26901067

Additional Document Info

start page

  • 356

end page

  • 8

volume

  • 48

number

  • 4