Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut Academic Article uri icon

Overview

MeSH Major

  • Chemoreceptor Cells
  • Intestinal Diseases, Parasitic
  • Intestinal Mucosa
  • Microbiota
  • TRPM Cation Channels

abstract

  • The intestinal epithelium forms an essential barrier separating host and microbiota. Protozoa and helminths are members of the gut microbiota of mammals, including humans; yet the many ways gut epithelial cells orchestrate responses to these Eukaryota remains unclear. Herein we show that tuft cells, taste-chemosensory epithelial cells, accumulate during parasite colonization and infection. Disruption of chemosensory signaling, via loss of Trpm5, abrogates expansion of tuft cells, goblet cells, eosinophils, and type-2 innate lymphoid cells (ILC2s) during parasite colonization. Tuft cells are the primary source of the parasite-induced cytokine, interleukin (IL)-25, which indirectly induces tuft cells expansion by promoting IL-13 production by ILCs. Our results identify intestinal tuft cells as critical sentinels in the gut epithelium, promote type-2 immunity in response to intestinal parasites.

publication date

  • February 4, 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5528851

Digital Object Identifier (DOI)

  • 10.1126/science.aaf1648

PubMed ID

  • 26847546

Additional Document Info