Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review Review uri icon


MeSH Major

  • Carcinoma, Adenoid Cystic
  • Lymphatic Metastasis
  • Salivary Gland Neoplasms


  • Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC-HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation.


publication date

  • March 2016



  • Review



  • eng

PubMed Central ID

  • PMC4833802

Digital Object Identifier (DOI)

  • 10.1007/s12325-016-0298-5

PubMed ID

  • 26895332

Additional Document Info

start page

  • 357

end page

  • 68


  • 33


  • 3