Noninvasive Detection of Inflammatory Changes in White Adipose Tissue by Label-Free Raman Spectroscopy Academic Article uri icon


MeSH Major

  • Adipose Tissue, White
  • Inflammation
  • Spectrum Analysis, Raman


  • White adipose tissue inflammation (WATi) has been linked to the pathogenesis of obesity-related diseases, including type 2 diabetes, cardiovascular disease, and cancer. In addition to the obese, a substantial number of normal and overweight individuals harbor WATi, putting them at increased risk for disease. We report the first technique that has the potential to detect WATi noninvasively. Here, we used Raman spectroscopy to detect WATi with excellent accuracy in both murine and human tissues. This is a potentially significant advance over current histopathological techniques for the detection of WATi, which rely on tissue excision and, therefore, are not practical for assessing disease risk in the absence of other identifying factors. Importantly, we show that noninvasive Raman spectroscopy can diagnose WATi in mice. Taken together, these results demonstrate the potential of Raman spectroscopy to provide objective risk assessment for future cardiometabolic complications in both normal weight and overweight/obese individuals.

publication date

  • February 16, 2016



  • Academic Article



  • eng

PubMed Central ID

  • PMC4799653

Digital Object Identifier (DOI)

  • 10.1021/acs.analchem.5b03696

PubMed ID

  • 26752499

Additional Document Info

start page

  • 2140

end page

  • 8


  • 88


  • 4