A specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: A new strategy for heart failure diagnostics and therapeutics Academic Article uri icon

Overview

MeSH Major

  • Heart
  • Heart Failure
  • Myocytes, Cardiac
  • Nanostructures

abstract

  • Results show that MSVs associate, internalize, and traffic in cardiovascular cells without any significant toxicity. Furthermore, MSVs accumulate in failing myocardium after intravenous administration, reaching intracellular regions of the cardiomyocytes. These findings represent a novel avenue to develop nanotechnology-based therapeutics and diagnostics in heart failure.

publication date

  • February 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4993041

Digital Object Identifier (DOI)

  • 10.1002/ejhf.463

PubMed ID

  • 26749465

Additional Document Info

start page

  • 169

end page

  • 78

volume

  • 18

number

  • 2